The first patients in a “historic” drug trial to test treatments for the coronavirus have been enrolled in Norway and Spain, World Health Organization officials announced Friday.

World health officials are testing four of the most promising drugs to fight COVID-19, including malaria medications chloroquine and hydroxychloroquine, an antiviral compound called Remdesivir, a combination of HIV drugs Lopinavir and Ritonavir and a combination of those drugs plus interferon-beta.

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